Oxymetholone Tablets Genesis 100 tabs/50 mg
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Pharmaceutical Name: Oxymetholone
Chemical structure: 17 beta-hydroxy-2-hydroxymethylene-17alpha-methyl-5 alpha-androstan-3-one
Molecular weight of base: 332.482
Effective dose: 50-150 mg / day orally
Oxymetholone is without a doubt the strongest and most visibly active steroid to date. Not only does it act very rapidly, it causes a virtual explosion of mass. Gains of up to 10 pounds in 2 weeks are not uncommon. This is largely due to a moderate to low androgenic effect combined with a high anabolic activity also mediated by non-AR mechanisms (mechanisms other than simply binding the androgen receptor). You can imagine that the gains made on oxymetholone aren't the leanest. You would note a drastic smoothing out of the muscle due to estrogen-related fat (lipolysis) and water retention. This lipolysis has been shown to be rather drastic. One study1 on long-term hemodialysis patients showed beyond a doubt the role that oxymetholone can play in causing hyperlipedemia. The fat deposition rate, post-hepatic (after processing by the liver), increased drastically in the oxymetholone group while numbers remained stable in the control group.
It has been suggested that the estrogenic effects of oxymetholone may not be as much mediated by estrogen, as by oxymetholone itself activating the estrogen receptor. Because there is little to no aromatisation off oxymetholone, the possible progestational effect was examined first. Similar to that of nandrolone perhaps. But a study2 testing the progestational effects of oxymetholone and methandrostenolone against those of testosterone as well as nandrolone and its metabolites showed that the progestagenic activity of oxymetholone wasn't even in the neighbourhood of that of testosterone, let alone nandrolone. Ruling out the possibility of progestagenic activity and aromatisation, that only left oxymetholone engaging in a structure with the estrogen receptor itself. Since it has an A-ring similar to that of estradiol (the prime estrogen) so this would be the most logical explanation. Since progesterone acts as an estrogen agonist, it would require circulating estrogen to negotiate such levels of water build-up as oxymetholone causes, so it seemed like a far-fetched idea to begin with.
The water component resulting from oxymetholone use is not be under-estimated either. The benefit of water retention is of course a lubrication of the joints, allowing the comfort of pain-free workouts even with extremely heavy weights, as well as the retention of more nutrients inside the cell, possibly leading to more permanent growth in muscle tissue. The downside to a massive water retention is that it gives you a rather puffed up look. A look not uncommon in off-season competitive bodybuilders and the heaviest classes of powerlifters. With the estrogen increase of course comes the increased risk of more side-effects such as gynocomastia (growth of breast tissue in men). Therefore its always advised that a cycle of oxymetholone is accompanied by the use of an anti-estrogen such as Nolvadex. Nolvadex, keeping in mind that aromatase enzyme is not involved, would be the wiser choice as it blocks the receptor for estrogen rather than the aromatase enzyme. Its wise to note as well that the gains from oxymetholone are largely mediated by estrogen, so reducing estrogen may reduce results as well.
oses are needed than with other oral steroids, so the relative risk increases as well.
Other notes I should mention about this compound are that oxymetholone's androgenic qualities are not linked to a 5-alpha reduced form. As a matter of fact it shows rather poor interaction with the 5AR enzyme, making it futile to treat a possible increase in hair loss with 5-alpha reductase-blocking products such as finasteride. Its androgenic component stems from the fact that oxymetholone is very much like Dihydrotestosterone were it not for the added 2-hydroxymethylene group. Since this group can be metabolically removed, that would leave methyl-DHT. A compound with a weaker affinity for the androgen receptor than straight DHT, but more active and with less affinity for the DHT-reducing enzyme 3beta hydroxysteroid dehydrogenase. Ultimately resulting in much stronger, instead of weaker androgenic effects than compounds that are actively 5-alpha reduced. This evens out largely, because the distribution is even across the body, where 5-alpha-reduction usually concentrates more potent androgenic forms in androgen responsive tissue such as skin and scalp.
The effect on the blood pressure is rather drastic, so its recommend that you use a anti-hypertensive drug in conjunction, especially if you already have a fairly high blood pressure. Here too the care and control of a physician is advised. Because of the HPTA (hypothalamic-pituitary-testicular axis) suppressive nature, the use of Clomid or Nolvadex and HCG is advised as well towards the end of your oxymetholone use. Lastly, oxymetholone also has an ill effect on the glucose tolerance5, causing borderline diabetic situations. Something to be weary of if you yourself have been diagnosed with similar problems already.
Oxymetholone is an exceptionally effective DHT derivative that has strong anabolic and mild androgenic effects, although it binds slightly to adrogen receptors, its androgenic activity is much stronger in practice. In the short term, it delivers massive muscle and strength gains, as its use is associated with strong water retention. By making it strong, it also reduces joint pain. It also significantly increases protosynthesis and red blood cell production. It is precisely oxymetholone that is associated with the awesome feeling of training pumping. It promotes the conversion of carbohydrates to glycogen and increases the level of prolactin in the body. The SHBG level in the body can reduce by more than 50%, thereby increasing the use of free TST to a significant extent. Its use is often associated with decreased appetite. To date, it is considered to be one of the strongest AAS available on the market and associated with a whole range of undesirable effects, which is the worst, the sustainability of its increments is minimal as it is mostly water left out of the body after it is dropped. It is exclusively used in volume-enhancing cycles. It's really interesting that his abused doses in sport are mostly lower than therapeutic doses. The use of oxymetholone entails a high risk of side effects.
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